First multisociety CKM syndrome guideline

Plain-language summary

The first comprehensive clinical practice guideline for cardiovascular-kidney-metabolic syndrome, building on the AHA 2023 Presidential Advisory and its staging system (stages 0 through 4) of the CKM continuum.

Key findings

• Four-stage CKM staging (0–4) from risk factors through subclinical to clinical disease.
• Co-authored by AHA/ACC and co-endorsed by ADA and ASN.

Population

Adults across the CKM risk continuum.

Primary source

2026 AHA/ACC/ADA/ASN CKM Guideline. J Am Coll Cardiol / Circulation. 2026.
https://www.jacc.org/doi/10.1016/j.jacc.2026.03.056