Evidence-based tools and teaching for the obesity–kidney interface — the metabolic-and-renal core of cardiovascular–kidney–metabolic (CKM) syndrome.
Nephrobesity is the clinical focus: how obesity and kidney disease drive one another, and how to manage them together. CKM is the wider framework that connects this axis to the heart. Start by task below.
Assess & stage
Interactive toolStage a patient (CKM 0–4)Place a patient on the cardiovascular–kidney–metabolic continuum and see what the stage implies.
Interactive toolRead the KDIGO risk grideGFR × albuminuria mapped to kidney and cardiovascular risk.
Choose therapy
Interactive toolOrgan-Protective Therapy SelectorBuild a CKM / obesity–kidney scenario and see how the RAAS inhibitor, SGLT2i, GLP-1 RA and finerenone layers are chosen — with trial evidence, thresholds and safety guards.
Interactive toolOrgan-protective therapy & the trialsSGLT2i, GLP-1 RA and finerenone side by side, with the landmark trials.
GuideSGLT2 vs GLP-1 vs finerenoneHow the three classes differ, combine, and fit the 2026 CKM guideline.
Obesity × kidney in special settings
Deep diveThe transplant candidateWeight thresholds, metabolic/bariatric surgery, and GLP-1 use before listing.
Deep divePost-transplant weight gainManaging obesity after transplant, including immunosuppressant interactions.
Deep diveObesity on dialysisThe obesity paradox, protein-energy wasting, and PD-specific considerations.
Look it up & teach
ReferenceObesity Medication TimelineFifty years of FDA-approved anti-obesity drugs — approval dates, indications, mechanisms, and pivotal-trial efficacy, from 1959 to 2026.
ReferenceStudy LibraryPrimary-source-bound trials with evidence tier and effect sizes.
CurriculumTen clinical domainsA structured, teachable curriculum for the obesity–kidney patient.
CasesTeaching casesShort, source-bound cases where kidney function changes the next step.
BackgroundCKM Learn hubPlain-language guides on the kidney–heart–metabolic connection.
Open the CKM ExplorerThe interactive core — stage a patient, read their heart–kidney risk, and match organ-protective therapy in about 15 minutes.Open the tool →
Educational use only. Content on this page is for health professionals, trainees, and students. It is not medical advice, does not establish a doctor–patient relationship, and does not replace clinical judgement or individualized care. Always consult a qualified clinician for care decisions. See the full medical disclaimer.