Euglycemic DKA with SGLT2 inhibitors (ADA/EASD consensus)

Evidence tier

Established · SGLT2i · Safety

Plain-language summary

The multisociety hyperglycemic-crises consensus report covering recognition and management of diabetic ketoacidosis, including euglycemic presentations relevant to SGLT2 inhibitor use — a key renal-safety consideration.

Key findings

Updated diagnostic and resolution criteria for DKA and HHS.
Euglycemic DKA is rare but high-risk, especially with fasting, acute illness, perioperative periods, dehydration, low-carbohydrate intake, or insulin deficiency.

Population

Adults with diabetes; relevant to SGLT2 inhibitor users.

What this does not prove

A consensus/guidance document, not an outcome trial. Euglycemic DKA is uncommon; framing should emphasise risk contexts, not routine incidence.

Primary source

Hyperglycemic Crises in Adults With Diabetes: A Consensus Report. Diabetes Care. 2024;47(8):1257–1275.
https://diabetesjournals.org/care/article/47/8/1257/156808/

Educational only

Paraphrased from the primary publication; not individual medical advice. Verify against the source before applying to care.