Obesity-related glomerulopathy: the defining pathology

Plain-language summary

The lesion of glomerulomegaly and adaptive FSGS driven by hyperfiltration — the histologic signature that distinguishes obesity-related glomerulopathy from primary FSGS.

Key findings

• Kambham 2001: first large biopsy series defining O-FSGS and glomerulomegaly.
• D’Agati 2016: comprehensive review of clinical/pathologic characteristics and pathogenesis.

Population

Patients with obesity and proteinuric kidney disease on biopsy.

Primary source

Kambham N, et al. Kidney Int. 2001;59:1498–1509. · D’Agati VD, et al. Nat Rev Nephrol. 2016;12:453–471.
https://www.nature.com/articles/nrneph.2016.75